Datasheet

ERRF Antibody
CATALOG NUMBER: 7289

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:ERRF Antibody can be used for detection of ERRF by Western blot at 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1201 - HeLa Cell Lysate
 2) Cat. No. 1288 - A20 Cell Lysate
 3) Cat. No. 17-001 - HeLa Cell Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 19 kDa

Observed: 15 kDa
IMMUNOGEN:ERRF antibody was raised against a 15 amino acid peptide near the carboxy terminus of human ERRF .

The immunogen is located within the last 50 amino acids of ERRF.
HOST SPECIES:Rabbit

Properties

PURIFICATION:ERRF Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:ERRF Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ERRF antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:ERRF Antibody: ERRF, Uncharacterized protein C1orf64
ACCESSION NO.:NP_849162
PROTEIN GI NO.:30519894
OFFICIAL SYMBOL:C1orf64
GENE ID:149563

Background

BACKGROUND:ERRF Antibody: The estrogen receptor-related factor (ERRF) is a recently identified protein whose expression is upregulated in multiple cell lines and primary breast cancer tumors. Increased ERRF expression was significantly associated with ER or progesterone receptor (PR) positivity even in HER2-negative tumors. This higher ERRF expression correlated with better disease-free survival and overall survival. In two ER-positive breast cancer cell lines, knockdown of ERRF suppressed cell growth in vitro and tumorigenesis in xenograft models, suggesting that ERRF plays a role in estrogen-ER-mediated breast cancer cell growth and may thus be a potential therapeutic target.
REFERENCES: 1) Su D, Fu X, Fan S, et al. Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells. Am. J. Pathol. 2012; 180:1189-201.

For Research Use Only