Datasheet

EPM2A Antibody
CATALOG NUMBER: 7023

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, ICC, IF, WB
APPLICATIONS:EPM2A antibody can be used for detection of EPM2A by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1221 - SW480 Cell Lysate
PREDICTED MOLECULAR WEIGHT:36 kDa
SPECIFICITY:At least four isoforms of EPM2A are known to exist; this antibody will detect all but the shortest isoform.
IMMUNOGEN:EPM2A antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human EPM2A.

The immunogen is located within amino acids 190 - 240 of EPM2A.
HOST SPECIES:Rabbit

Properties

PURIFICATION:EPM2A Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:EPM2A Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:EPM2A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:EPM2A Antibody: EPM2, MELF, Laforin, Lafora PTPase, LAFPTPase
ACCESSION NO.:NP_005661
PROTEIN GI NO.:11321613
OFFICIAL SYMBOL:EPM2A
GENE ID:7957

Background

BACKGROUND:EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
REFERENCES: 1) Minassian BA, Lee JR, Herbrick JA, et al. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat. Genet. 1998; 20:171-4.
2) Worby CA, Gentry MS, and Dixon JE. Laforin, a dual specificity phosphatase that dephosphorylates complex carbohydrates. J. Biol. Chem. 2006; 281:30412-8.

For Research Use Only