Datasheet

EphA10 Antibody
CATALOG NUMBER: 5253

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:EphA10 antibody can be used for detection of EphA10 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1210 - HEK293 Cell Lysate
IMMUNOGEN:EphA10 antibody was raised against a 14 amino acid synthetic peptide of near the amino terminus of human EphA10.

The immunogen is located within amino acids 120 - 170 of EphA10.
HOST SPECIES:Rabbit

Properties

PURIFICATION:EphA10 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:EphA10 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:EphA10 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:EphA10 Antibody: Ephrin type-A receptor 10
ACCESSION NO.:NP_001092909
PROTEIN GI NO.:150456460
OFFICIAL SYMBOL:EPHA10
GENE ID:284656

Background

BACKGROUND:EphA10 Antibody: Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility of neuronal and endothelial cells in central nervous system function and in development. Eph receptors can be divided into two subgroups: EphA and EphB. In mammals, the EphA class consists of eight members (EphA 1-7 and 10) that in general bind to ephrin-A members linked to the cell membrane through a glycosylphosphatidylinositol linkage. The EphB class consists of six members (EphB 1-6) that in general bind ephrin-B members that transverse the cell membrane. The Ephrin / EPH signaling pathway networks with the WNT signaling pathway during embryogenesis, tissue regeneration, and carcinogenesis. Recent studies show that Eph/EFN might be relevant in normal B-cell biology and could represent new potential prognostic markers and therapeutic targets for CLL.
REFERENCES: 1) Flanagan JG and Vanderhaeghen P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci.1998;.21:309-45.
2) Frisen J, Holmberg J, and Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. EMBO J.1999; 18:5159-65.
3) Eph Nomenclature Committee. Unified nomenclature for Eph family receptors and their ligands, the ephrins. Cell1997; 90:403-4.
4) Holder N and Klein R. Eph receptors and ephrins: effectors of morphogenesis, Development1999; 126:2033-44.

For Research Use Only