EpCAM Recombinant Protein Cat. No.: 96-270

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psi-iconSpecifications
SPECIES:Rhesus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 24 - Lys 265
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:28.2 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:EPCAM, TACSTD1, TROP1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1/4, KSA, M4S1, MIC18, MK1
ACCESSION NO.:NP_001035118.1
OFFICIAL SYMBOL:EPCAM
GENE ID:677680
psi-iconBackground and References
BACKGROUND:EpCAM is also known as CO171A,; EGP; EGP40; GA7332; KSA; M4S; MIC18; MK1; TROP1; hEGP2, and is a pan-epithelial differentiation antigen that is expressed on almost all carcinomas as 17-1A(mAb) antigen. Its constitutional function is being elucidated. It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signaling and polarity. The epithelial cell adhesion molecule (Ep-CAM) is known to express in most epithelial malignancies and was reported as a tumor marker or a candidate of molecular targeting therapy. Ep-CAM cross signaling with N-cadherin involves Pi3K, resulting in the abrogation of the cadherin adhesion complexes in epithelial cells was reported. And Epithelial cell adhesion molecule (Ep-CAM) recently received increased attention as a prognostic factor in breast cancer.
REFERENCES:1) Linnenbach, et al., 1993, Mol Cell Biol 13 (3): 1507–15.
2) Akita H, et al., 2011, Oncogene.
3) Winter MJ, et al., 2007, Mol Cell Biochem. 302(1-2):19-26.
4) Schmidt M, et al., 2011, Breast Cancer Res Treat. 125(3):637-46.

FOR RESEARCH USE ONLY.

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