EPAS1 Antibody Cat. No.: 55-359

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
IMMUNOGEN: This EPAS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-150 amino acids from the N-terminal region of human EPAS1.
TESTED APPLICATIONS: Flow, WB
APPLICATIONS: For WB starting dilution is: 1:1000

For FACS starting dilution is: 1:10~50
PREDICTED MOLECULAR WEIGHT: 96 kDa

psi-iconProperties
PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:EPAS1
ALTERNATE NAMES:Endothelial PAS domain-containing protein 1, EPAS-1, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, bHLHe73, HIF-1-alpha-like factor, HLF, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Member of PAS protein 2, PAS domain-containing protein 2, EPAS1, BHLHE73, HIF2A, MOP2, PASD2
ACCESSION NO.:Q99814
PROTEIN GI NO.:32470617
GENE ID:2034
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.
REFERENCES:1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
2) Yi, X., et al. Science 329(5987):75-78(2010)
3) Bougatef, F., et al. PLoS ONE(8), E12265 (2010) :
4) Hossein Ghaderian, S.M., et al. Pathology 42(5):446-453(2010)

ANTIBODIES FOR RESEARCH USE ONLY.

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