VTIPSSCCTS FISKKIPENR VVSYQLANGS ICPKAGVIFI TKKGHKICTD PKLLWVQRHI QKLDAKKNQP SKGAKAVRTK FAVQRRRGNS TEV
TESTED APPLICATIONS:
BIOLOGICAL ACTIVITY:
Biological activity was determined by its ability to chemoattract murine lymphocytes using a concentration range of 10 - 100 ng/mL.
Properties
PURITY:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
PHYSICAL STATE:
Lyophilized
STORAGE CONDITIONS:
The lyophilized Eotaxin-2 recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted Eotaxin-2 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing Eotaxin-2 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemoattracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multipotential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation). Recombinant murine Eotaxin-2 is an 10.3 kDa protein containing 93 amino acid residues.
Specifications
