Datasheet

ELOVL7 Antibody
CATALOG NUMBER: 5641

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Rat: (100%), Bovine: (100%)
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:ELOVL7 antibody can be used for detection of ELOVL7 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1304 - Human Liver Tissue Lysate
 2) Cat. No. 10-201 - Human Liver Tissue Slide
IMMUNOGEN:ELOVL7 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human ELOVL7.

The immunogen is located within amino acids 40 - 90 of ELOVL7.
HOST SPECIES:Rabbit

Properties

PURIFICATION:ELOVL7 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:ELOVL7 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:ELOVL7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:ELOVL7 Antibody: Elongation of very long chain fatty acids protein 7, 3-keto acyl-CoA synthase ELOVL7, ELOVL FA elongase 7
ACCESSION NO.:NP_001098028
PROTEIN GI NO.:157388949
OFFICIAL SYMBOL:ELOVL7
GENE ID:79993

Background

BACKGROUND:ELOVL7 Antibody: Lipogenesis is a key event in the energy storage system and is controlled by the transcription factor sterol regulatory element-binding protein (SREBP)-1. Elongation of very long chain fatty acids protein 7 (ELOVL7) is a member of fatty acyl-CoA elongase gene family that elongates saturated very-long-chain fatty acids (SVLFA, C20:0-) and has been suggested to be involved in prostate cancer growth through saturated long-chain fatty acid metabolism. The metabolic pathways of long-chain fatty acids play an important role in the maintenance of membrane lipid composition and the generation of cell signaling precursor molecules such as eicosanoids and sphingosine-1 phosphate. Overexpression of ELOVL7 results in lipid accumulation in differentiated adipocytes; its expression is regulated by the microRNA miR-219.
REFERENCES: 1) Tamura K, Makino A, Hullin-Matsuda F, et al. Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through saturated long-chain fatty acid metabolism. Cancer Res.2009; 69:8133-40.
2) Leonard AE, Pereira SL, Sprecher H, et al. Elongation of long-chain fatty acids. Prog. Lipid Res.2004; 43:36-54.
3) Shin D, Shin JY, McManus MT, et al. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Ann. Neurol.2009; 66:843-57.

For Research Use Only