Datasheet

DRGX Antibody
CATALOG NUMBER: 6517

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:DRGX antibody can be used for detection of DRGX by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1464 - Rat Liver Tissue Lysate
SPECIFICITY:At least two are known to exist; DRGX antibody is predicted to not cross-react with other Homeodomain proteins.
IMMUNOGEN:DRGX antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human DRGX.

The immunogen is located within the last 50 amino acids of DRGX.
HOST SPECIES:Chicken

Properties

PURIFICATION:DRGX Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:DRGX Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:DRGX antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgY
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:DRGX Antibody: DRG11, PRRXL1, Dorsal root ganglia homeobox protein, Paired-related homeobox protein-like 1
ACCESSION NO.:NP_001073989
PROTEIN GI NO.:122937484
OFFICIAL SYMBOL:DRGX
GENE ID:644168

Background

BACKGROUND:DRGX Antibody: DRGX, also known as DRG11 or PRRXL1, is a paired homeodomain transcription factor, and was initially cloned from a differential hybridization screen aimed at identifying dorsal root ganglia (DRG)-specific genes. DRGX is a key regulator of the differentiation of the spinal cord neuronal circuit dedicated to the processing of nociceptive information. DRGX is also important for the formation of the whisker-related somatosensory maps in the principal sensory nucleus of the trigeminal nerve, thalamus and somatosensory cortex.
REFERENCES: 1) Saito T, Greenwood A, Sun Q et al. Identification by differential RT-PCR of a novel paired homeodomain protein specifically expressed in sensory neurons and a subset of their CNS targets. Mol. Cell. Neurosci. 1995; 6:280-92.
2) Chen ZF, Rebelo S, White F et al. The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. Neuron 2001; 31:59-73.
3) Ding YQ, Yin J, Xu HM, et al. Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires a paired homeodomain transcription factor, Drg11. J. Neurosci. 2003; 23:7246-54
4) Rebelo S, Lopes C, Lima D, et al. Expression of a Prrxl1 alternative splice variant during the development of the mouse nociceptive system. Int. J. Dev. Biol. 2009; 53:1089-95.

For Research Use Only