Datasheet

DRAK1 Antibody
CATALOG NUMBER: 2147

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Rabbit: (73%)
TESTED APPLICATIONS:ELISA, ICC, IF, WB
APPLICATIONS:DRAK1 antibody can be used for detection of DRAK1 by Western blot at 1 μg/mL. An approximately 50 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.

Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1202 - A431 Cell Lysate
 2) Cat. No. 1206 - MOLT4 Cell Lysate
 3) Cat. No. 17-006 - MOLT-4 Cell Slide
PREDICTED MOLECULAR WEIGHT:50 kDa
SPECIFICITY:No cross responses to DRAK2, DAP or ZIP kinases.
IMMUNOGEN:DRAK1 antibody was raised against a peptide corresponding to amino acids near the amino terminus of human DRAK1.

The immunogen is located within the first 50 amino acids of DRAK1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:DRAK1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:DRAK1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:DRAK1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:DRAK1 Antibody: DRAK1, DRAK1, DAP kinase-related apoptosis-inducing protein kinase 1
ACCESSION NO.:Q9UEE5
PROTEIN GI NO.:14423930
OFFICIAL SYMBOL:STK17A
GENE ID:9263

Background

BACKGROUND:DRAK1 Antibody: Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
REFERENCES: 1) Sanjo H, Kawai T, Akira S. DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J Biol Chem 1998;273:29066-71

For Research Use Only