DELE Antibody Cat. No.: 6919

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (71%)
IMMUNOGEN: DELE antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human DELE.

The immunogen is located within the first 50 amino acids of DELE.
TESTED APPLICATIONS: ELISA, IF, WB
APPLICATIONS: DELE antibody can be used for detection of DELE by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1463 - Rat Brain Tissue Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide

psi-iconProperties
PURIFICATION:DELE Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:DELE Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:DELE antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:KIAA0141
ALTERNATE NAMES:DELE Antibody: DELE, DELE, Death ligand signal enhancer
ACCESSION NO.:NP_055588
PROTEIN GI NO.:217330656
GENE ID:9812
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:DELE Antibody: DELE is a recently identified DAP3-binding protein that is thought to be important in the induction of death receptor-mediated apoptosis. Transfected cells that stably express DELE were found to be susceptible to apoptosis induction by TNF-α and TRAIL, whereas reducing DELE expression by siRNA rescued these cells from apoptosis induction. Furthermore, the reduction of DELE expression also inhibited the activation of caspase-3, caspase-8 and caspase-9 following stimulation by TNF-α, anti-Fas, or TRAIL, indicating the importance of DELE in apoptosis mediated by death receptors.
REFERENCES:1) Harada T, Iwai A, Miyazaki T. Identification of DELE, a novel DAP-binding protein which is crucial for death receptor-mediated apoptosis induction. Apoptosis 2010; 15:1247-55.

ANTIBODIES FOR RESEARCH USE ONLY.

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