DDX48 Antibody Cat. No.: 28-492

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: C. elegans, Dog, Human, Mouse, Rat, Zebrafish
IMMUNOGEN: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DDX48.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: DDX48 antibody can be used for detection of DDX48 by ELISA at 1:312500. DDX48 antibody can be used for detection of DDX48 by western blot at 1.25 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
POSITIVE CONTROL:1) Cat. No. 1211 - HepG2 Cell Lysate
PREDICTED MOLECULAR WEIGHT: 45 kDa

psi-iconProperties
PURIFICATION:Antibody is purified by protein A chromatography method.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:For short periods of storage (days) store at 4˚C. For longer periods of storage, store DDX48 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:EIF4A3
ALTERNATE NAMES:DDX48, DDX48, MUK34, NUK34, NMP265, eIF4AIII
ACCESSION NO.:NP_055555
PROTEIN GI NO.:7661920
GENE ID:9775
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:DDX48 encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a nuclear matrix protein. Its amino acid sequence is highly similar to the amino acid sequences of the translation initiation factors eIF4AI and eIF4AII, two other members of the DEAD box protein family.
REFERENCES:1) Lee, S., et al., (2002) Cancer Lett. 184 (2), 197-206.

ANTIBODIES FOR RESEARCH USE ONLY.

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