| HOST SPECIES: | Mouse |
| SPECIES REACTIVITY: | Human |
| IMMUNOGEN: | A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN. |
| TESTED APPLICATIONS: | ELISA, IHC-P, WB |
| APPLICATIONS: | DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL. Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested. |
| POSITIVE CONTROL: | 1) Cat. No. 1384 - Human Uterus Tissue Lysate |
| 2) Cat. No. 1369 - Human Lymph node Tissue Lysate |
Specifications| PURIFICATION: | DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG. |
| CLONALITY: | Monoclonal |
| ISOTYPE: | IgG1,k |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | DC-SIGN monoclonal antibody can be stored at -20˚C, stable for one year. |
| OFFICIAL SYMBOL: | CD209 |
| ALTERNATE NAMES: | DC-SIGN Antibody [8B6] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1 |
| ACCESSION NO.: | Q9NNX6 |
| PROTEIN GI NO.: | 46396012 |
| GENE ID: | 30835 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum. |
| REFERENCES: | 1) Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97. | 2) Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001;75:4664-72. | 3) Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85. | 4) Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42. |
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