Cytokeratin 15 Antibody [SPM190] Cat. No.: 33-800

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Bovine, Human, Rat
IMMUNOGEN: An amino acid sequence from the C-terminal portion of the human protein was used as the immunogen for the Cytokeratin 15 antibody.
TESTED APPLICATIONS: Flow, IF, IHC-Fr, IHC-P, WB
APPLICATIONS: Flow Cytometry: 0.5-1 ug/million cells in 0.1ml

Immunofluorescence: 1-2 ug/ml

WB: 0.5-1 ug/ml

Immunohistochemistry (FFPE & Frozen): 0.5-1 ug/ml for 30 min at RT

Optimal dilution of the Cytokeratin 15 antibody should be determined by the researcher.

psi-iconProperties
PURIFICATION:Protein G affinity chromatography
CLONALITY:Monoclonal
ISOTYPE:IgG2a, kappa
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.1 mg/ml BSA and 0.05% sodium azide
CONCENTRATION:0.2 mg/mL
STORAGE CONDITIONS:Aliquot and Store at 2-8˚C. Avoid freez-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:KRT15
ALTERNATE NAMES:KRT15, CK15, K15, K1CO
GENE ID:3866
USER NOTE:Optimal dilutions for each application to be determined by the researcher
psi-iconBackground and References
BACKGROUND:Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.

ANTIBODIES FOR RESEARCH USE ONLY.

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