Cyclin-Dependent Kinase 7 Recombinant Protein Cat. No.: 91-657

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:E. coli
SEQUENCE:Met1-Phe346
FUSION TAG:N-6 His tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant protein can be used for biological assays. For research use only.
psi-iconProperties
PURITY:Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
PREDICTED MOLECULAR WEIGHT:41.2 kD
PHYSICAL STATE:Liquid
BUFFER:Supplied as a 0.2 um filtered solution of 50mM PB,100mM NaCl,5mM DTT,20%Glycerol pH7.0. It is not recommended to reconstitute to a concentration less than 100 ug/ml.
STORAGE CONDITIONS:Store at -20˚C, stable for 6 months after receipt.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:Cyclin-Dependent Kinase 7, 39 kDa Protein Kinase, p39 Mo15, CDK-Activating Kinase 1, Cell Division Protein Kinase 7, Serine/Threonine-Protein Kinase 1, TFIIH Basal Transcription Factor Complex Kinase Subunit, CDK7, CAK, CAK1, CDKN7, MO15, STK1
ACCESSION NO.:P50613
OFFICIAL SYMBOL:CDK7
GENE ID:1022
psi-iconBackground and References
BACKGROUND:Cyclin-dependent kinase 7 (CDK7) belongs to the CMGC Ser/Thr superfamily, CDK7 colocalizes with PRKCI in the cytoplasm and nucleus, translocating from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides. As a serine/threonine kinase CDK7 is involved in cell cycle control and RNA polymerase II-mediated RNA transcription. In addition, CDK7 is the catalytic subunit of the CDK-activating kinase complex, which phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11.

FOR RESEARCH USE ONLY.

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