Datasheet

CTRP5 Antibody
CATALOG NUMBER: 3573

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Rat: (93%), Mouse: (93%)
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:CTRP5 antibody can be used for the detection of CTRP5 by Western blot at 1 - 4 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1223 - Caco-2 Cell Lysate
SPECIFICITY:Adipokine proteins are often highly modified post-translationally and migrate in SDS-PAGE at positions other than their predicted size.
IMMUNOGEN:CTRP5 antibody was raised against a 15 amino acid synthetic peptide from near the center of human CTRP5.

The immunogen is located within amino acids 90 - 140 of CTRP5.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CTRP5 Antibody is immunoaffinity purified IgG.
PHYSICAL STATE:Liquid
BUFFER:CTRP5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CTRP5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CTRP5 Antibody: CTRP5, CTRP5, UNQ303/PRO344, Complement C1q tumor necrosis factor-related protein 5
ACCESSION NO.:AAQ88749
PROTEIN GI NO.:37181891
OFFICIAL SYMBOL:C1QTNF5
GENE ID:114902

Background

BACKGROUND:CTRP5 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. CTRP5 has been suggested to be involved in age-related macular degeneration.
REFERENCES: 1) CTRP5 antibody can be stored at 4˚C, stable for one year. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005; 115:911-9.
2) Tsao T-S, Lodish HF, and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Euro. J. Pharmacol. 2002; 440:213-21.
3) Wong GW, Wang J, Hug C, et al. A family of Acrp30/ adiponectin structural and functional paralogs. Proc. Natl. Acad. Sci. USA 2004; 101:10302-7.
4) Shapiro L and Scherer PE. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor. Curr. Biol. 1998; 8:335-8.

For Research Use Only