CSHL1 Antibody Cat. No.: 56-820

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
IMMUNOGEN: This CSHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-185 amino acids from the C-terminal region of human CSHL1.
TESTED APPLICATIONS: IHC-P, WB
APPLICATIONS: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50
PREDICTED MOLECULAR WEIGHT: 25 kDa

psi-iconProperties
PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:CSHL1
ALTERNATE NAMES:Chorionic somatomammotropin hormone-like 1, Chorionic somatomammotropin-like, Lactogen-like, CSHL1, CSHP1, CSL
ACCESSION NO.:Q14406
PROTEIN GI NO.:313104096
GENE ID:1444
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified.
REFERENCES:1) Bailey, S.D., et al. Diabetes Care (2010) In press :
2) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
3) Misra-Press, A., et al. J. Biol. Chem. 269(37):23220-23229(1994)
4) MacLeod, J.N., et al. J. Biol. Chem. 267(20):14219-14226(1992)

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