CREB-binding Protein highly active Recombinant Protein Cat. No.: 90-344

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:Sf21 cells
SEQUENCE:Mouse CREB-binding protein fused at the C-terminus to a His-tag.
FUSION TAG:His Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: ~50-100ng are required for standard HAT assay.
psi-iconProperties
PURITY:>95% (SDS-PAGE)
PHYSICAL STATE:Liquid
BUFFER:In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride, 0.2% NP-40, 50-100mM imidazole and 10% glycerol.
CONCENTRATION:Lot dependent (0.2-0.5mg/ml)
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -80˚C.
psi-iconAdditional Info
ALTERNATE NAMES:CBP, CREBBP
ACCESSION NO.:P45481
PROTEIN GI NO.:341940549
OFFICIAL SYMBOL:Crebbp
GENE ID:12914
psi-iconBackground and References
BACKGROUND:CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.

FOR RESEARCH USE ONLY.

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