Datasheet

CPEB1 Antibody
CATALOG NUMBER: 4687

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:CPEB1 antibody can be used for detection of CPEB1 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1463 - Rat Brain Tissue Lysate
IMMUNOGEN:CPEB1 antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus of human CPEB1.

The immunogen is located within amino acids 50 - 100 of CPEB1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CPEB1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CPEB1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CPEB1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CPEB1 Antibody: CEBP, CPEB, CPEB-1, CPE-BP1, hCPEB-1, Cytoplasmic polyadenylation element-binding protein 1
ACCESSION NO.:Q9BZB8
PROTEIN GI NO.:74762720
OFFICIAL SYMBOL:CPEB1
GENE ID:64506

Background

BACKGROUND:CPEB1 Antibody: CPEB1 is an RNA binding protein that contains an RNA-recognition motif and a zinc finger-containing region found in a wide range of vertebrates and invertebrates. CPEB1 forms the nucleus of a complex of factors that regulate poly(A) elongation and promotes polyadenylation-induced translation. CPEB1 mediates many diverse biological processes such as germ cell development, cell division and senescence, and synaptic plasticity. Recently, it was discovered that CPEB1 is involved in beta-catenin mRNA translation and cell migration in astrocytes as well as regulating hypoxia-inducible factor (HIF)-1 expression, demonstrating the wide range of processes in which CPEB1 plays a role. At least four isoforms of CPEB1 are known to exist.
REFERENCES: 1) Richter JD. CPEB: a life in translation. Trends in Biochem. Sci.2007; 32:179-85.
2) Jones KJ, Korb E, Kundel MA, et al. CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes. Glia2008; 56:1401-13.
3) Hagele S, Kuhn U, Boning M, et al. Cytoplasmic polyadenylation element binding protein (CPEB)1 and 2 bind to the HIF-1alpha mRNA 3’UTR and modulate HIF-1 alpha protein expression. Biochem. J.2008; epub.

For Research Use Only