COVID-19 (SARS-CoV-2) Small Molecules

COVID-19 (SARS-CoV-2, 2019-nCoV) Small Molecules | ProSci Inc. 



Viral Entry

ProductCat. No.TargetAntiviral Activity
Amastatin . hydrochloride 10-016 Viral entry ANPEP (Aminopeptidas N) Viral Replication
Camostat . mesylate 10-017 Viral entry TMPRSS2 Viral Replication
Nafamostat . mesylate 10-031 Viral entry TMPRSS2 Viral Replication
Umifenovir . HCl [Arbidol] 10-048 Viral entry Fusion into host cells Viral Replication


Lysosome/Endosome

ProductCat. No.TargetAntiviral Activity
Chloroquine . diphosphate 10-018 Lysosome function Zinc ionophore Viral Replication
Hydroxychloroquine . sulfate 10-019 Lysosome function Zinc ionophore Viral Replication
Niclosamide 10-033 Endosome acidification Viral Replication
Niclosamide . ethanolamine 10-034 Endosome acidification Viral Replication


Viral Portease

ProductCat. No.TargetAntiviral Activity
Darunavir 10-021 Papain-like viral protease (PLVP) Viral Maturation/Replication
Darunavir . ethanolate 10-022 Papain-like viral protease (PLVP) Viral Maturation/Replication
Famotidine 10-026 SARS-CoV-2 papain-like protease (PLpro) Viral Replication
Mycophenolic acid 10-030 SARS-CoV-2 papain-like protease (PLpro) Viral Replication
Ebselen 10-023 Main Protease (Mpro)/3C-like Protease Viral Transcription/Replication
Shikonin 10-045 Main Protease (Mpro)/3C-like Protease Viral Transcription/Replication
Rosuvastatin . calcium salt 10-041 Main Protease Mpro Viral Replication
Saquinavir . mesylate 10-044 Main Protease Mpro Viral Replication


Viral RdRps

ProductCat. No.TargetAntiviral Activity
Remdesivir 10-037 RNA-dependent RNA polymerases (RdRps) Viral Transcription/Replication
Remdesivir Metabolite (GS-441524) 10-038 RNA-dependent RNA polymerases (RdRps) Viral Transcription/Replication
EIDD-2801 10-024 RNA-dependent RNA polymerases (RdRps) Viral Transcription/Replication
Favipiravir 10-027 RNA-dependent RNA polymerases (RdRps) Viral Transcription/Replication
Elbasvir 10-025 RdRP, Papain-like Proteinase and Helicase Viral Replication
Ribavirin 10-039 RNA-dependent RNA polymerases (RdRps) RNA capping activity Viral mutation rates Immunomodulation Viral Transcription/Replication


JAK Immunomodulation

ProductCat. No.TargetAntiviral Activity
Ruxolitinib (free base) 10-042 JAK1/JAK2 Immunomodulation Viral Replication
Ruxolitinib . phosphate salt 10-043 JAK1/JAK2 Immunomodulation Viral Replication
Tofacitinib 10-046 JAK1/JAK2 Immunomodulation Viral Replication
Tofacitinib . citrate 10-047 JAK1/JAK2 Immunomodulation Viral Replication


Other Chemicals

ProductCat. No.TargetAntiviral Activity
Imatinib . mesylate 10-028 Virion fusion with endosomal membrane Viral Replication
Nelfinavir . mesylate 10-032 Post-entry inhibitor Viral Replication
Nitazoxanide 10-035 Viral hemagglutinin Viral IE2 Viral Maturation/Transcription/Replication
Oseltamivir . phosphate 10-036 Viral neuraminidase Release of viral particles Viral Replication
Lopinavir 10-029 Coronavirus endopeptidase C30 (CEP_C30) Viral Maturation/Replication
Ritonavir 10-040 Coronavirus endopeptidase C30 (CEP_C30) Viral Maturation/Replication


COVID-19 (SARS-CoV-2, 2019-nCoV) Reagents

ProSci Incorporated has developed and manufactured SARS-CoV-2 antibodies, antigens, and other reagents related to cellular entry: ACE2 receptor, TMPRSSR2 protease, and furin enzyme. ProSci is continuously adding new SARS-CoV-2 reagents for spike, S1, S2, nucleocapsid, membrane, envelope including llama single domain antibodies and recombinant proteins.

ProSci Incorporated has also launched matched SARS-CoV-2 (COVID-19, 2019-nCoV) antibody pairs validated by sandwich ELISA. These spike antibody pair and nucleocapsid antibody pairs are suitable for COVID-19 antigen test, ELISA, lateral flow and other immunoassay.