Coronin 7 Antibody Cat. No.: 6451

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (94%)
IMMUNOGEN: Coronin 7 antibody was raised against an 17 amino acid synthetic peptide near the carboxy terminus of human Coronin 7.

The immunogen is located within the last 50 amino acids of Coronin 7.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: Coronin 7 antibody can be used for detection of Coronin 7 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
SPECIFICITY: Multiple isoforms of Coronin 7 are known to exist
POSITIVE CONTROL:1) Cat. No. 1462 - Rat Lung Tissue Lysate

psi-iconProperties
PURIFICATION:Coronin 7 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Coronin 7 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Coronin 7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:CORO7
ALTERNATE NAMES:Coronin 7 Antibody: CRN7, POD1, 0610011B16Rik, Coronin-7, 70 kDa WD repeat tumor rejection antigen homolog, Crn7
ACCESSION NO.:NP_078811
PROTEIN GI NO.:168229161
GENE ID:79585
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Coronin 7 Antibody: Coronins, such as Coronin 7, constitute an evolutionarily conserved family of WD-repeat actin-binding proteins whose function is thought to be regulating the cytoskeleton. Unlike other cytoplasmically localized Coronins, Coronin 7 localizes in part to the Golgi complex and is thought to play a role in Golgi complex morphology and function. Other experiments indicate that Coronin 7 interacts with the anti-proliferative protein TOB1 and enhances its degradation though the SCF ubiquitin ligase (E3) complex.
REFERENCES:1) Rybakin V, Stumpf N, Schulze A, et al. Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus. FEBS Lett. 2004; 573:161-7.
2) Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi. J. Biol. Chem. 2006; 281:31070-8.
3) Watanabe M, Suzuki T, Kim M, et al. Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob. FEBS Lett. 2011; 585:65-70.

ANTIBODIES FOR RESEARCH USE ONLY.

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