| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| HOMOLOGY: | Predicted species reactivity based on immunogen sequence: Bovine: (95%) |
| IMMUNOGEN: | COMMD7 antibody was raised against a 19 amino acid peptide near the center of human COMMD7. The immunogen is located within amino acids 90 - 140 of COMMD7. |
| TESTED APPLICATIONS: | ELISA, IF, IHC-P, WB |
| APPLICATIONS: | COMMD7 antibody can be used for detection of COMMD7 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. |
| SPECIFICITY: | COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7. |
| POSITIVE CONTROL: | 1) Cat. No. 1406 - Mouse Spleen Tissue Lysate |
| 2) Cat. No. 10-901 - Human Spleen Tissue Slide | |
| PREDICTED MOLECULAR WEIGHT: | Predicted: 22 kDa Observed: 21 kDa |
Specifications| PURIFICATION: | COMMD7 antibody is affinity chromatography purified via peptide column. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | COMMD7 antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | COMMD7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| OFFICIAL SYMBOL: | COMMD7 |
| ALTERNATE NAMES: | COMMD7 Antibody: C20orf92, dJ1085F17.3, C20orf92, COMM domain-containing protein 7 |
| ACCESSION NO.: | NP_444269 |
| PROTEIN GI NO.: | 151101369 |
| GENE ID: | 149951 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4). |
| REFERENCES: | 1) Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6. | 2) Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32. | 3) Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry 2007; 46:3116-28. | 4) Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412. |
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