Collagen Type 1 Antibody Cat. No.: 36-350

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Bovine, Cat, Dog, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep
IMMUNOGEN: Synthetic peptide (human sequence) corresponding to the C-terminal end of the N-terminal three quarter collagen fragment (Col1 ¾).
TESTED APPLICATIONS: ICC
APPLICATIONS: Immunocytochemistry: (2.5-10ug/ml). Optimal conditions must be determined individually for each application.
SPECIFICITY: Recognizes rat and bovine collagen type 1 cleavage site. Based on sequence identity should also recognize human, mouse, guinea pig, dog, cat, donkey, pig, cow, sheep and chicken collagen type 1.

psi-iconProperties
PURIFICATION:Antigen affinity purified.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Liquid. In PBS with 1 mg/ml BSA and 0.02% sodium azide.
CONCENTRATION:200 ug/ml
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:N/A
ALTERNATE NAMES:COL1; alpha-1 Type I Collagen
ACCESSION NO.:N/A
PROTEIN GI NO.:N/A
GENE ID:N/A
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The proteolysis of collagens plays an important role in numerous physiological and pathological situations such as morphogenesis, wound healing, arthritis, arteriosclerosis and tumor metastasis. Triple helical type I collagens are made up of two alpha1 (I) and one alpha2 (I) chains, and are found in skin, tendon, ligament and interstitial tissues. Due to their fibrillary structure native collagens are resistant to most proteases. They are substrates for certain matrix metalloproteinases (MMPs), which constitute a family of zinc-dependent enzymes catalyzing the degradation of extracellular matrix components. Initial MMP-8 dependent cleavage of collagen into the characteristic ¾ and ¼ fragments has been shown to enable MMP-9 diffusion along the protein helix with preferential binding to the collagen ¾ fragment tail. Finally, untwisting of the helix end results in the local denaturation of the triple helical structure.

ANTIBODIES FOR RESEARCH USE ONLY.

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