CNRIP1 Antibody Cat. No.: 7303

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (93%)
IMMUNOGEN: CNRIP1 antibody was raised against a 15 amino acid peptide near the center of human CNRIP1.

The immunogen is located within amino acids 50 - 100 of CNRIP1.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: CNRIP1 antibody can be used for detection of CNRIP1 by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
SPECIFICITY: At least two isoforms of CNRIP1 are known to exist; this antibody will detect both isoforms.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
PREDICTED MOLECULAR WEIGHT: Predicted: 18 kDa

Observed: 16 kDa

psi-iconProperties
PURIFICATION:CNRIP1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:CNRIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CNRIP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:CNRIP1
ALTERNATE NAMES:CNRIP1 Antibody: CRIP1, C2orf32, CB1 cannabinoid receptor-interacting protein 1, CRIP-1
ACCESSION NO.:NP_056278
PROTEIN GI NO.:24308071
GENE ID:25927
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CNRIP1 Antibody: The CNRIP1 (cannabinoid receptor interacting protein 1) protein is a G-protein coupled receptor which interacts with the C-terminal tail of cannabinoid receptor 1 (CB1) and is thought to play a role in synaptic plasticity, analgesia, appetite, and neuroprotection. One isoform of CNRIP1, CNRIP1a, modulates the constitutive CB1 receptor activity in the central nervous system (CNS), while the role of the shorter isoform CNRIP1b is yet unknown. CNRIP1 has been suggested as a potential target for CNS drug discovery.
REFERENCES:1) Niehaus JL, Liu Y, Wallis KT, et al. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Mol. Pharmacol. 2007; 72:1557-66.
2) Smith TH, Sim-Selley LJ, and Selley DE. Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery. Br. J. Pharm. 2010; 160:454-66.

ANTIBODIES FOR RESEARCH USE ONLY.

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