CMPK2 Antibody Cat. No.: 7063

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: CMPK2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human CMPK2.

The immunogen is located within amino acids 370 - 420 of CMPK2.
TESTED APPLICATIONS: ELISA, IF, WB
APPLICATIONS: CMPK2 antibody can be used for detection of CMPK2 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: Multiple isoforms of CMPK2 are known to exist.
POSITIVE CONTROL:1) Cat. No. 1462 - Rat Lung Tissue Lysate
 2) Cat. No. 10-101 - Human Lung Tissue Slide
PREDICTED MOLECULAR WEIGHT: 49 kDa

psi-iconProperties
PURIFICATION:CMPK2 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:CMPK2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CMPK2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:CMPK2
ALTERNATE NAMES:CMPK2 Antibody: TYKi, TMPK2, UMP-CMPK2, UMP-CMP kinase 2, mitochondrial, Nucleoside-diphosphate kinase
ACCESSION NO.:NP_997198
PROTEIN GI NO.:117606370
GENE ID:129607
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CMPK2 Antibody: UMP-CMP kinase 2 (CMPK2) is the first nucleoside monophosphate kinase that has been identified in human mitochondria. It is a component of the salvage pathway for nucleotide synthesis that may participate in terminal differentiation of monocytic cells. There are two distinct domains of CMPK2: the N-terminal domain with unknown function and the C-terminal domain with the kinase function, suggesting that CMPK2 may be a bifunctional protein with other biological functions in addition to its UMP-CMP kinase activity. CMPK2 may participate in dUTP and dCTP synthesis and is responsible for phosphorylation of dCMP and dUMP in mitochondria. CMPK2 is actively involved in macrophage activation and the inflammatory response
REFERENCES:1) Xu Y, Johansson M, Karlsson A. Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria. J. Biol. Chem. 2008; 283:1563-71.
2) Chen YL, Lin DW, and Chang ZF. Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation. Genes Cells 2008; 13:679-89.
3) Arima T, Akiyoshi H, and Fujii S. Characterization of pyrimidine nucleoside monophosphokinase in normal and malignant tissues. Cancer Res. 1977; 37:1593-7.
4) Goertsches RH, Hecker M, Koczan D, et al. Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS. Pharmacogenomics 2010;11:147-61.

ANTIBODIES FOR RESEARCH USE ONLY.

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