CMKLR1 Antibody [BZ332] Cat. No.: 51-034

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Human
IMMUNOGEN: CMKLR1 monoclonal antibody was raised against a peptide near the N-Terminus of CMKLR1 (Human).
TESTED APPLICATIONS: Flow, IHC
APPLICATIONS: CMKLR1 antibody can be used in Western Blot, immunohistochemistry starting at 10 μg/mL, and immunoprecipitation.
SPECIFICITY: Recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic ce ...

psi-iconProperties
PURIFICATION:Protein G Column
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS, pH 7.4, 0.09% sodium azide.
CONCENTRATION:1 mg/ml
STORAGE CONDITIONS:Store CMKLR1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:CMKLR1
ALTERNATE NAMES:CMKLR1, Chemokine receptor-like 1, DEZ, CHEMERINR, Resolvin E1 receptor, RVER1, Chemokine-like receptor 1, ChemR23, G-protein coupled receptor DEZ
ACCESSION NO.:Q99788
PROTEIN GI NO.:17380487
GENE ID:1240
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC's are recruited to sites of bleeding and tissue damage

ANTIBODIES FOR RESEARCH USE ONLY.

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