Clusterin nuclear form Recombinant Protein Cat. No.: 90-051

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:E. coli
SEQUENCE:Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
FUSION TAG:His Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: N/A
psi-iconProperties
PURITY:>90% (SDS-PAGE).

Endotoxin level is less than 1EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Liquid
BUFFER:0.2um-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
CONCENTRATION:1mg/ml
STORAGE CONDITIONS:Working aliquots are stable for up to 3 months when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2
ACCESSION NO.:Q549A5
PROTEIN GI NO.:81887962
OFFICIAL SYMBOL:Clu
GENE ID:12759
psi-iconBackground and References
BACKGROUND:Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80-kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

FOR RESEARCH USE ONLY.

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