Datasheet

CLAUDIN4 Antibody
CATALOG NUMBER: 7025

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (94%)
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:CLAUDIN4 antibody can be used for detection of CLAUDIN4 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1201 - HeLa Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 23 kDa

Observed: 23 kDa
SPECIFICITY:At least four isoforms of CLAUDIN4 are known to exist; CLAUDIN4 antibody will detect all four isoforms
IMMUNOGEN:CLAUDIN4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human CLAUDIN4.

The immunogen is located within the last 50 amino acids of CLAUDIN4.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CLAUDIN4 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CLAUDIN4 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CLAUDIN4 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CLAUDIN4 Antibody: CPER, CPE-R, CPETR, CPETR1, WBSCR8, hCPE-R, CPER, Claudin-4, Clostridium perfringens enterotoxin receptor
ACCESSION NO.:NP_001296
PROTEIN GI NO.:4502877
OFFICIAL SYMBOL:CLDN4
GENE ID:1364

Background

BACKGROUND:CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.
REFERENCES: 1) Mitic LL, Unger VM, and Anderson JM. Expression, solubilization, and biochemical characterization of the tight junction transmembrane protein claudin-4. Protein Sci. 2003; 12:218-27.
2) Paperna T, Peoples R, Wang YK, et al. Genes for the CPE receptor (CPETR1) and the human homolog of RVP1 (CPETR2) are localized within the Williams-Beuren syndrome deletion. Genomics 1998; 54:453-9.
3) Morin PJ. Claudin proteins in human cancer: promising new targets for diagnosis and therapy. Cancer Res. 2005; 65:9603-6.

For Research Use Only