Datasheet

CHCHD7 Antibody
CATALOG NUMBER: 7143

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (71%)
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:CHCHD7 antibody can be used for detection of CHCHD7 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1464 - Rat Liver Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 11 kDa
SPECIFICITY:Three alternatively spliced transcript variants have been observed. CHCHD7 is predicted to not cross-react to other members of the CHCHD family.
IMMUNOGEN:Rabbit polyclonal CHCHD7 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human CHCHD7.

The immunogen is located within the last 50 amino acids of CHCHD7.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CHCHD7 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CHCHD7 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CHCHD7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CHCHD7 Antibody: COX23, Coiled-coil-helix-coiled-coil-helix domain-containing protein 7
ACCESSION NO.:NP_077276
PROTEIN GI NO.:64464338
OFFICIAL SYMBOL:CHCHD7
GENE ID:79145

Background

BACKGROUND:CHCHD7 Antibody: CHCHD7 is a newly identified member of a multifamily of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. Northern blot analysis revealed that the gene is ubiquitously expressed. Its biological function is unknown and the gene has hitherto not been associated with neoplasia. CHCHD7 and PLAG1 are located head-to-head about 500 bp apart in 8q12. A chromosomal aberration involving CHCHD7 is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland.
REFERENCES: 1) Asp J, Persson F, Kost-Alimova M, et al. CHCHD7-PLAG1 and TCEA1-PLAG1 gene fusions resulting from cryptic, intrachromosomal 8q rearrangements in pleomorphic salivary gland adenomas. Genes Chromosomes Cancer 2006; 45:820-8.
2) Nishimura S, Watanabe T, Mizoshita K, et al. Genome-wide association study identified three major QTL for carcass weight including the PLAG1-CHCHD7 QTN for stature in Japanese Black cattle. BMC Genet. 2012; 13:40.
3) Matsuyama A, Hisaoka M, and Hashimoto H. PLAG1 expression in cutaneous mixed tumors: an immunohistochemical and molecular genetic study. Virchows Arch. 2011; 459:539-45.

For Research Use Only