Datasheet

CHADL Antibody
CATALOG NUMBER: 8423

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC, WB
APPLICATIONS:CHADL antibody can be used for the detection of CHADL by Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 84 kDa

Observed: 86 kDa
SPECIFICITY:CHADL antibody is human, mouse and rat reactive. CHADL antibody is predicted to not cross-react with Chondroadherin protein.
IMMUNOGEN:CHADL antibody was raised against a 19 amino acid peptide from near the carboxy terminus of human CHADL.

The immunogen is located within the last 50 amino acids of CHADL.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CHADL Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CHADL Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CHADL antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Chondoadherin-like protein, SLRR4B
ACCESSION NO.:NP_612490
PROTEIN GI NO.:194440719
OFFICIAL SYMBOL:CHADL
GENE ID:150356

Background

BACKGROUND:The Chondroadherin-like (CHADL) protein, also known as SLRR4B, is homologous to the Chondroadherin protein and is expressed cartillaginous tissues (1). Like Chondroadherin, CHADL belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily and plays a significant role in the regulation of chondrocyte growth and proliferation (1,2). CHADL is thought to play a negative regualtory role in collagen fibrillogenesis and chondrocyte differentiation (1).
REFERENCES: 1) Tillgren V, Ho JC, Onnerfjord P, et al. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentitation. J. Biol. Chem. 2015; 290:918-25.
2) Neame PJ, Sommarin Y, Boynton RE, et al. The structure of a 38-kDa leucine-rich protein (chondroadherin) isolated from bovine cartilage. J. Biol. Chem. 1994; 269:21547-54.

For Research Use Only