Datasheet

CDO1 Antibody
CATALOG NUMBER: 8137

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (84%)
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:CDO1 antibody can be used for detection of CDO1 by Western blot at 1 - 2 μg/ml.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1464 - Rat Liver Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 22 kDa

Observed: 24 kDa
SPECIFICITY:CDO1 antibody is human, mouse and rat reactive.
IMMUNOGEN:CDO1 antibody was raised against a 19 amino acid peptide near the amino terminus of human CDO1.

The immunogen is located within amino acids 30 - 80 of CDO1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:CDO1 antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:CDO1 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:CDO1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:Cysteine dioxygenase type I, CDO, CDO-I, Cysteine dioxygenase type 1
ACCESSION NO.:NP_001792
PROTEIN GI NO.:56786147
OFFICIAL SYMBOL:CDO1
GENE ID:1036

Background

BACKGROUND:CDO1 (cysteine dioxygenase, type I) belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis (1). CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine (1,2). CDO1 exists as a monomer and is expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart (1). CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell (3,4).
REFERENCES: 1) McCann KP, Akbari MT, Williams AC, et al. Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA. Biochim. Biophys. Acta 1994; 1209:107-10.
2) Ye S, Wu X, Wei L, et al. An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor. J. Biol. Chem. 2007; 282:3391-402.
3) Booken N, Gratchev A, Utikal J, et al. Sezary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. Leukemia 2008; 22:393-9.
4) Wrangle J, Machida EO, Danilova L, et al. Functional identification of cancer-specific methylation of CDO1, HOXA9, and TAC1 for the diagnosis of lung cancer. Clin. Cancer Res. 2014; 20:1856-64.

For Research Use Only