| SPECIES: | Cynomolgus monkey |
| SOURCE SPECIES: | HEK293 cells |
| SEQUENCE: | Ala 19 - His 240 |
| FUSION TAG: | His Tag |
| TESTED APPLICATIONS: | WB |
| APPLICATIONS: | This recombinant protein can be used for WB. For research use only. |
Specifications| PURITY: | >95% as determined by SDS-PAGE. |
| PREDICTED MOLECULAR WEIGHT: | 27.3 kDa |
| PHYSICAL STATE: | Lyophilized |
| BUFFER: | PBS, pH7.4 |
| STORAGE CONDITIONS: | Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles. |
| ALTERNATE NAMES: | CD86, B7-2, B70, CD28LG2, LAB72, MGC34413 |
| ACCESSION NO.: | Q9BDM4 |
| OFFICIAL SYMBOL: | CD86 |
| GENE ID: | 714390 |
| BACKGROUND: | Cluster of Differentiation 86 (CD86) is also known as B-lymphocyte activation antigen B7-2, is a type I membrane protein that is a member of the immunoglobulin superfamily, and is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B72 is expressed at low levels on monocytes and can be upregulated through interferon γ. CD86 is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with CD80 to prime T cells. Recent study has revealed that B7-2 promotes the generation of a mature APC repertoire and promotes APC function and survival. Furthermore, the B7 proteins are also involved in innate immune responses by activating NF-κB-signaling pathway in macrophages. CD86 thus is regarded as a promising candidate for immune therapy. CD86+ macrophages in Hodgkin lymphoma patients are an independent marker for potential nonresponse to firstline-therapy. |
| REFERENCES: | 1) Chen C, et al., 1994, J. Immunol. 152 (10): 4929–36. | 2) Yadav, D. et al., 2007, J. Immunol. 178: 6236-6241. | 3) Steidl C, et al., 2010, N. Engl. J. Med. 362 (10): 875–85. |
FOR RESEARCH USE ONLY.
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