Datasheet

CD69 Antibody [H1.2F3] (APC)
CATALOG NUMBER: 76-826

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Mouse
TESTED APPLICATIONS:Flow
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
SPECIFICITY:The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27-33 kDA type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM).
HOST SPECIES:Hamster

Properties

PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C and should be protected from prolonged exposure to light. Do not freeze.
CLONALITY:Monoclonal
ISOTYPE:Armenian Hamster IgG
CONJUGATE:APC

Additional Info

ALTERNATE NAMES:AIM, VEA, AI452015, 5830438K24Rik, Cd69
OFFICIAL SYMBOL:Cd69
GENE ID:12515

Background

BACKGROUND:The H1.2F3 monoclonal antibody specifically reacts with human CD69, the 27-33 kDA type II transmembrane protein also known as the very early activation antigen (VEA) or the activation inducer molecule (AIM). It is expressed as a disulfide-linked dimer on B cells, T cells, NK cells, platelets, eosinophils, and neutrophils. It increases in expression upon cell activation and seems to serve a role as a signaling receptor.
REFERENCES: 1) Ge, A. Z., Butcher, E. C. (1994). Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF--beta- ligand.Gene,138(1), 201-206.
2) Onoe, T., Ohdan, H., Tokita, D., Shishida, M., Tanaka, Y., Hara, H., ... Asahara, T. (2005). Liver sinusoidal endothelial cells tolerize T cells across MHC barriers in mice.The Journal of Immunology,175(1), 139-146.
3) St-Jacques, S., Cymerman, U. R. S. Z. U. L. A., Pece, N. A. D. I. A., Letarte, M. (1994). Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.Endocrinology,134(6), 2645-2657.

For Research Use Only