CD47 Recombinant Protein Cat. No.: 97-039

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psi-iconSpecifications
SPECIES:Rat
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 19 - Lys 140
FUSION TAG:Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:40.4 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD47,MER6,IAP,OA3
ACCESSION NO.:P97829
OFFICIAL SYMBOL:CD47
GENE ID:29364
psi-iconBackground and References
BACKGROUND:Leukocyte surface antigen CD47 is also known as Antigenic surface determinant protein OA3, Integrin-associated protein (IAP) and Protein MER6. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain. CD47 is very broadly distributed on normal adult tissues. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins and plays an important role in memory formation and synaptic plasticity in the hippocampus by similarity. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. CD47 Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.
REFERENCES:1) Lindberg F.P., et al., 1993, J. Cell Biol. 123:485-496.
2) Latour S., et al., 2001, J. Immunol. 167:2547-2554.
3) Piccio L., et al., 2005, Blood 105:2421-2427.

FOR RESEARCH USE ONLY.

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