CD40 Recombinant Protein Cat. No.: 96-086

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Glu 21 - Arg 193
FUSION TAG:C-His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
BIOLOGICAL ACTIVITY: Immobilized Human CD40, His Tag at 5ug/mL (100 uL/well) can bind Mouse CD40 Ligand, Fc Tag with a linear range of 2.6-16 ng/mL.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:20 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
ACCESSION NO.:P25942-1
OFFICIAL SYMBOL:CD40
GENE ID:958
psi-iconBackground and References
BACKGROUND:Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).
REFERENCES:1) Ferrari S., et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98:12614-12619,
2) Singh J., et al., 1998, Protein Sci. 7:1124-1135.

FOR RESEARCH USE ONLY.

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