This recombinant protein can be used for WB. For research use only.
BIOLOGICAL ACTIVITY:
Immobilized Human CD40, His Tag at 5ug/mL (100 uL/well) can bind Mouse CD40 Ligand, Fc Tag with a linear range of 2.6-16 ng/mL.
Properties
PURITY:
>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:
20 kDa
PHYSICAL STATE:
Lyophilized
BUFFER:
PBS, pH7.4
STORAGE CONDITIONS:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Additional Info
ALTERNATE NAMES:
CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
ACCESSION NO.:
P25942-1
OFFICIAL SYMBOL:
CD40
GENE ID:
958
Background and References
BACKGROUND:
Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).
REFERENCES:
1) Ferrari S., et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98:12614-12619,
2) Singh J., et al., 1998, Protein Sci. 7:1124-1135.
Specifications
