CD40 Recombinant Protein Cat. No.: 90-269

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193).
FUSION TAG:Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Blocks the binding of CD40L to CD40.
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS. Reconstitute with 50 μl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
CONCENTRATION:1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5, CD40L Receptor
ACCESSION NO.:P25942
PROTEIN GI NO.:4507581
OFFICIAL SYMBOL:CD40
GENE ID:958
psi-iconBackground and References
BACKGROUND:CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.

FOR RESEARCH USE ONLY.

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