CD40 Antibody [1C10] (APC) Cat. No.: 98-766

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Mouse
IMMUNOGEN: sCD40
TESTED APPLICATIONS: Flow, IHC-Fr, IHC-P, WB, WB-Non Reducing
APPLICATIONS: CD40 Antibody [1C10] for use in flow cytometry assays.
SPECIFICITY: CD40

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2a
CONJUGATE:APC
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3 and a stabilizing agent
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Cd40
ALTERNATE NAMES:TNFRSF5, Bp50
ACCESSION NO.:P27512
GENE ID:21939
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow with the levels of CD40 expression increasing thereafter during B cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. CD40 has a central role in B cell growth and differentiation, and signaling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors.

ANTIBODIES FOR RESEARCH USE ONLY.

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