This recombinant protein can be used for WB. For research use only.
Properties
PURITY:
>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:
42.3 kDa
PHYSICAL STATE:
Lyophilized
BUFFER:
PBS, pH7.4
STORAGE CONDITIONS:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Additional Info
ALTERNATE NAMES:
CD4, CD4mut, LEU3
ACCESSION NO.:
G7N5T8
Background and References
BACKGROUND:
T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.
REFERENCES:
1) Brady RL, et al., 1993, Science 260 (5110): 979–83.
2) Zeitlmann, L., et al., 2001, J. Biol. Chem. (United States) 276 (12): 9123–32.
3) Rudd CE, et al., 2010, J. Immunol. 185 (5): 2645–9.
4) Rudd CE, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (14): 5190–4.
Specifications
