CD4 Antibody [GK1.5] (PE-Texas Red) Cat. No.: 98-587

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psi-iconSpecifications
HOST SPECIES:Rat
SPECIES REACTIVITY: Mouse
IMMUNOGEN: Mouse CTL clone V4
TESTED APPLICATIONS: ELISA, ICC, IHC-Fr, IP
APPLICATIONS: CD4 Antibody [GK1.5] for use in flow cytometry assays.
SPECIFICITY: CD4

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG2b
CONJUGATE:PE-Texas Red
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3 and a stabilizing agent
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Cd4
ALTERNATE NAMES:L3T4, Ly-4
ACCESSION NO.:P06332
GENE ID:12504
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors. The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells. In vivo and in vitro treatment with the GK1.5 monoclonal antibody effectively depletes CD4+ cells. GK1.5 also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.

ANTIBODIES FOR RESEARCH USE ONLY.

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