CD3e Antibody [145-2C11] (PE-Cy5) Cat. No.: 98-563

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psi-iconSpecifications
HOST SPECIES:Hamster
SPECIES REACTIVITY: Mouse
IMMUNOGEN: H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone BM10-37
TESTED APPLICATIONS: WB
APPLICATIONS: CD3e Antibody [145-2C11] for use in flow cytometry assays.
SPECIFICITY: CD3epsilon

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG
CONJUGATE:PE-Cy5
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3 and a stabilizing agent
CONCENTRATION:0.1 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Cd3e
ALTERNATE NAMES:CD3 epsilon
ACCESSION NO.:P22646
GENE ID:12501
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:CD3epsilon, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging in size from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). It is expressed on all T cells of all mouse strains. CD3 plays a major role in signaling during antigen recognition, leading to T-cell activation. The 145-2C11 monoclonal antibody recognizes an epitope on the 25 kDa epsilon chain of the CD3/TCR complex. In the presence of Fc receptor-bearing accessory cells, soluble 145-2C11 can activate primed and naïve T cell in vitro. 145-2C11 can also induce redirected lysis of specific target cells by CTL clones and it can block lysis of specific target cells by antigen-specific CTL’s. Immobilized 145-2C11 can activate both normal T lymphocytes and cloned T cell lines. Under certain conditions, T cell activation by 145-2C11 may result in apoptotic cell death.

ANTIBODIES FOR RESEARCH USE ONLY.

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