CD38 Recombinant Protein Cat. No.: 11-441

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:Leu 45 - Thr 304
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 31.7 kDa. The protein migrates as 38-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:31.7 kDa
PHYSICAL STATE:Lyophilized
BUFFER:50 mM MES, 100 mM NaCl, pH6.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD38,T10,cADPr hydrolase 1
ACCESSION NO.:NP_031672.2
OFFICIAL SYMBOL:Cd38
GENE ID:12494
psi-iconBackground and References
BACKGROUND:CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
REFERENCES:1) Orciani M., et al., 2008, J. Cell. Biochem. 105 (3): 905–12.
2) Nata K., et al., 1997, Gene 186 (2): 285–92.
3) Malavasi F., et al., 2008, Physiol. Rev. 88 (3): 841–86.

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