CD30 Ligand / TNFSF8 Recombinant Protein Cat. No.: 11-465

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 63 - Asp 234
FUSION TAG:Mouse IgG Fc Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 46.5 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:46.5 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD30-L,CD153,TNFSF8,CD30L,CD30LG,CD153 antigen,CD30 antigen ligand,CD30 Ligand
ACCESSION NO.:NP_001235.1
OFFICIAL SYMBOL:TNFSF8
GENE ID:944
psi-iconBackground and References
BACKGROUND:CD30 ligand (CD30L) and CD30 are interacting cellsurface glycoproteins that are members of the tumour necrosis factor (TNF) and tumour necrosis factor receptor (TNFR) superfamilies. In humans, CD30L is expressed at high levels on activated T cells. There is conflicting evidence with regard to cell surface expression of CD30L on primary human B cells. An initial report of constitutive CD30L expression on peripheral blood B cells33 has not been substantiated.
REFERENCES:1) Marín ND., et al. 2017, Tuberculosis (Edinb)., 102, 8-15.
2) Kennedy MK., et al. 2006, Immunology., 118(2), 143-52.
3) Horie R., et al. 1998, Semin Immunol., 10(6), 457-70.

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