CD30 Antibody [mCD30.1] Cat. No.: 76-016

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psi-iconSpecifications
HOST SPECIES:Hamster
SPECIES REACTIVITY: Mouse
TESTED APPLICATIONS: Flow, Func
SPECIFICITY: The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
CLONALITY:Monoclonal
ISOTYPE:Armenian Hamster IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C . Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:Tnfrsf8
ALTERNATE NAMES:Ki, Cd30, Ki-1, D1S166E, Tnfrsf8
GENE ID:21941
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on activated T, B, NK, and monocyte cells. Its expression on activated T lymphocytes is regulated by cytokines and CD28. The ligand for CD30 is CD153. It has been suggested that the molecule plays a role in the protection against autoimmunity and the regulation of Th1 and Th2 cytokine secretion.
REFERENCES:1) Siegmund, T., Armitage, N., Wicker, L. S., Peterson, L. B., Todd, J. A., Lyons, P. A. (2000). Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9. 2.Diabetes,49(9), 1612-1616.
2) Falini, B., Pileri, S., Pizzolo, G., D, H., Flenghi, L., Stirpe, F., ... Stein, H. (1995). CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy.BLOOD-NEW YORK-,85, 1-1.
3) Heath, W. R., Kurts, C., Caminschi, I., Carbone, F. R., Miller, J. F. (1999). CD 30 prevents T‐cell responses to non‐lymphoid tissues.Immunological reviews,169(1), 23-29.

ANTIBODIES FOR RESEARCH USE ONLY.

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