CD3 Epsilon Recombinant Protein Cat. No.: 96-166

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psi-iconSpecifications
SPECIES:Cynomolgus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 22 - Asp 117
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>97% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:11.7 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:T3E, TCRE, CD3E, CD3-epsilon
ACCESSION NO.:Q95LI5.2
OFFICIAL SYMBOL:CD3E
GENE ID:102133065
psi-iconBackground and References
BACKGROUND:CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
REFERENCES:1) Gold DP, et al., 1986, Nature 321 (6068): 431–4.
2) Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60.
3) de Saint Basile G, et al., 2004, J. Clin. Invest. 114 (10): 1512–7.
4) Wong S, et al., 1991, Clin. Exp. Immunol. 83 (1): 69–73.

FOR RESEARCH USE ONLY.

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