CD3 epsilon&CD3 gamma Heterodimer Recombinant Protein Cat. No.: 11-551

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Asp 23 - Asp 126 (CD3E) & Gln 23 - Ser 116 (CD3G)
FUSION TAG:His Tag & Fc Tag & Flag Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:Human CD3E&CD3G Heterodimer Protein, Fc,His Tag&Fc,Flag Tag is produced by co-expression of CD3E and CD3G, has a calculated MW of 39.2 kDa (CD3E) and 38.6 kDa (CD3G). Subunit CD3E is fused with a human IgG1 Fc tag at the C-terminus, followed by a polyhist
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:39.2 kDa (CD3E) & 38.6 kDa (CD3G)
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD3 epsilon & CD3 gamma,CD3E & CD3G
ACCESSION NO.:NP_000724.1 (CD3E) & AAI13831.1 (CD3G)
OFFICIAL SYMBOL:CD3E
GENE ID:916
psi-iconBackground and References
BACKGROUND:T-cell surface glycoprotein CD3 delta & CD3 gamma chain, also known as CD3D & CD3G or CD3D&CD3G respectively, are single-pass type I membrane proteins. CD3D, together with CD3- epsilon(CD3E) , CD3-gamma and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. T cell receptor-CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
REFERENCES:1) Gold DP, et al., 1986, Nature 321 (6068): 431–4.
2) Clevers HC, et al., 1988, Proc. Natl. Acad. Sci. U.S.A. 85 (21): 8156–60.
3) Gil J, et al., 2011, J Clin Invest, 121(10):3872-6.
4) Lu X, et al.,2011, Hematology, 16(3):185-9.

FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.