CD3 delta Recombinant Protein Cat. No.: 96-160

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psi-iconSpecifications
SPECIES:Cynomolgus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Phe 22 - Ala 105
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>90% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:14.3 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CD3D, CD3-DELTA, T3D
ACCESSION NO.:Q95LI8
OFFICIAL SYMBOL:CD3D
GENE ID:102133701
psi-iconBackground and References
BACKGROUND:CD3D is also known as CD3-DELTA, T3D, and is a single-pass type I membrane protein. CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. Defects in CD3D cause severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T-/B+/NK+ SCID) which is a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
REFERENCES:1) Gil J, et al., 2011, J Clin Invest, 121(10):3872-6.
2) Lu X, et al.,2011, Hematology, 16(3):185-9.
3) Kim ST, et al., 2010, J Immunol, 185(5):2951-9.

FOR RESEARCH USE ONLY.

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