CD3 Antibody [UCHT1] Cat. No.: 76-280

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psi-iconSpecifications
HOST SPECIES:Mouse
SPECIES REACTIVITY: Human
TESTED APPLICATIONS: Flow, Func, IF, IHC, IP, WB
SPECIFICITY: The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex.

psi-iconProperties
PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
CLONALITY:Monoclonal
ISOTYPE:Mouse IgG1, kappa
CONJUGATE:Unconjugated
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C . Do not freeze.

psi-iconAdditional Info
OFFICIAL SYMBOL:CD3E
ALTERNATE NAMES:T3E, TCRE, IMD18, CD3E
GENE ID:916
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The UCHT1 monoclonal antibody specifically reacts with the epsilon chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains gamma, delta, and epsilon chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3epsilon. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
REFERENCES:1) Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
2) McMichael, A. J. (1987). Leucocyte typing III.Oxford University Press, Oxford. Norton AJ, Isaacson PG (1985)
3) Beverley, P. C., Callard, R. E. (1981). Distinctive functional characteristics of human T lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.European journal of immunology,11(4), 329-334.

ANTIBODIES FOR RESEARCH USE ONLY.

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