CD28H / IGPR-1 Recombinant Protein Cat. No.: 11-383

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:HEK293 cells
SEQUENCE:Leu 23 - Gly 150
FUSION TAG:His Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.9 kDa. The protein migrates as 22-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>90% as determined by reduced SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:15.9 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:TMIGD2,IGPR1
ACCESSION NO.:AAH15655
OFFICIAL SYMBOL:TMIGD2
GENE ID:126259
psi-iconBackground and References
BACKGROUND:CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1,is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue,the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
REFERENCES:1) Evans E.J., et al., 2005, Nat. Immunol. 6:271-279.
2) Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46.
3) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.

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