Datasheet

CD28 Antibody [JJ319]
CATALOG NUMBER: 76-744

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Rat
TESTED APPLICATIONS:Flow, Func
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
SPECIFICITY:The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily.
HOST SPECIES:Mouse

Properties

PURIFICATION:The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
PHYSICAL STATE:liquid
BUFFER:Phosphate-buffered aqueous solution, ph7.2.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:The product should be stored undiluted at 4˚C . Do not freeze.
CLONALITY:Monoclonal
ISOTYPE:Mouse IgG1
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:CD28RNA, Cd28
OFFICIAL SYMBOL:Cd28
GENE ID:25660

Background

BACKGROUND:The JJ319 monoclonal antibody specifically reacts with rat CD28, a 44 kDa glycoprotein member of the immunoglobulin superfamily. CD28 is expressed on alpha/beta TCR+ T cells, some gamma/delta TCR+ T cells and a subset of NK cells. CD28 is a costimulatory receptor required for T cell activation. Its ligands are CD80 (B7-1) and CD86 (B7-2).
REFERENCES: 1) Nandi, D., Gross, J. A., Allison, J. P. (1994). CD28-mediated costimulation is necessary for optimal proliferation of murine NK cells.The Journal of Immunology,152(7), 3361-3369.
2) Gross, J. A., Callas, E. L. E. N. I., Allison, J. P. (1992). Identification and distribution of the costimulatory receptor CD28 in the mouse.The Journal of Immunology,149(2), 380-388.
3) Nishio, M., Spielman, J., Lee, R. K., Nelson, D. L., Podack, E. R. (1996). CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T cell lysis.The Journal of Immunology,157(10), 4347-4353.

For Research Use Only