CD275 [B7-H2] non-lytic Recombinant Protein Cat. No.: 90-437

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:CHO cells
SEQUENCE:The extracellular domain of mouse CD275 [B7-H2] (aa 48-279) is fused to the N-terminus of the Fc region of a mutant mouse IgG2a.
FUSION TAG:Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Measured by its binding ability in a functional ELISA. Immobilized human ICOS at 1ug/ml (100ul/well) can bind biotinylated B7-H2 (mouse):Fc (mouse) (rec.) (non-lytic) with a linear range of 0.1-1.0ug/ml. Optimal dilutions should be determined by each laboratory for each application.
psi-iconProperties
PURITY:≥98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Lyophilized from 0.2um-filtered solution in PBS. Reconstitute at 100 μg/ml in sterile PBS.
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1
ACCESSION NO.:NP_056605
PROTEIN GI NO.:7657220
OFFICIAL SYMBOL:Icosl
GENE ID:50723
psi-iconBackground and References
BACKGROUND:Mouse CD275 (B7-H2) is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.

FOR RESEARCH USE ONLY.

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