CD27 Recombinant Protein Cat. No.: 90-390

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psi-iconSpecifications
SPECIES:Human
SOURCE SPECIES:CHO cells
SEQUENCE:The extracellular domain of human CD27 (aa 21-192) is fused to the N-terminus of the Fc region of human IgG1.
FUSION TAG:Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Measured by its ability to inhibit the proliferation of mouse T cells induced by CD27 ligand and anti-CD3.
psi-iconProperties
PURITY:≥98% (SDS-PAGE).

Endotoxin level is less than 0.06EU/ μg protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Lyophilized from 0.2um-filtered solution in PBS. Reconstitute with 100 μl sterile water. Add 1X PBS to the desired protein concentration.
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C. Working aliquots are stable for up to 3 months when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:T Cell Activation Antigen CD27, T14, TNFRSF7, Tumor Necrosis Factor Receptor Superfamily Member 7, S152
ACCESSION NO.:AAH12160
PROTEIN GI NO.:15082491
OFFICIAL SYMBOL:CD27
GENE ID:939
psi-iconBackground and References
BACKGROUND:CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

FOR RESEARCH USE ONLY.

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